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连接子 Connexon： 连接子应用于ADC和PROTAC，在PROTAC中，连接PROTAC两部分（一个用于识别E3泛素连接酶的小肽残基和一个可以被靶向蛋白识别的配体）的中间连接体。连接体的长度是随机选择的，长度从12个碳到20多个碳不等。一个最佳的连接体会使得两个部分（目标蛋白和E3连接酶）之间拥有最大程度的相互作用，从而导致目标蛋白的高效泛素化和最终降解。 在ADC中，连接子通过化学键将抗体与毒素连接，帮助抗体选择性地将细胞毒性药物递送到肿瘤细胞，并准确地在肿瘤部位释放细胞毒性药物；连接子在ADC的制备和储存以及体循环过程中，也发挥着重要作用。ADC中连接子分为可裂解和不可裂解两大类。
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