脂肪酸修饰侧链是一种小分子修饰物，是改变胰岛素类产品药代动力学行为的重要因素之一。多肽类药物在临床上存在半衰期较短易被降解的问题，在多肽类药物中引入脂肪酸修饰侧链，可以增加药物的疏水性，提高生物半衰期，从而降低用药剂量、减少用药频率。 在脂肪酸修饰药物的开发中，可根据脂肪酸修饰侧链的结构特征及制备工艺，充分评估其质量对产品安全性、有效性和质量可控性的潜在影响，需要重点关注脂肪酸修饰侧链相关杂质的监测与控制，包括工艺相关有机物、修饰异构体、降解物杂质、遗传毒性杂质和元素杂质等。
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![1118767-15-9|tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu|tert-butyl 17-{[(2S)-1-(tert-butoxy)-4-({2-[2-({[2-(2-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethoxy}ethoxy)ethyl]carbamoyl}methoxy)ethoxy]ethyl}carbamoyl)-1-oxobutan-2-yl]carbamoyl}heptadecanoate](https://images.chemany.com/attachments/products_new/svg/1118767-15-9.svg)
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![2460751-66-8|Fmoc-L-Lys[C20-OtBu-Glu(OtBu)-AEEA-AEEA]-OH|(2S)-6-[2-(2-{2-[2-(2-{2-[(4R)-5-(tert-butoxy)-4-[20-(tert-butoxy)-20-oxoicosanamido]-5-oxopentanamido]ethoxy}ethoxy)acetamido]ethoxy}ethoxy)acetamido]-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanoic acid](https://images.chemany.com/attachments/products_new/svg/2460751-66-8.svg)
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