螺环 spiro： 脂环烃分子中两个碳环共有一个碳原子称为螺环烃，可形成螺环化合物。螺环结构与平面的芳香结构相比，有着更大的空间三维结构，而且结构更加新颖，从成药性角度分析，化合物结构中含有太多平面的芳香环结构时成药性下降，在药物分子中引入螺环不仅更容易获得专利保护，也有助于提升化合物稳定性，改善药代动力学性质，因此，螺环在药物设计中的应用已经逐渐引起药物化学家的重视，目前已有很多上市药物均含有螺环结构。
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